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After their mother was diagnosed with breast cancer and tested positive for a BRCA2 genetic mutation, Caroline Pruce (then 26) and her sister, Emily Lubin (then 23) decided to undergo genetic testing themselves and found that they, too, carry the BRCA2 mutation.
Mutations to the BRCA1 and BRCA2 genes account for the majority of hereditary breast cancer treatment. People who carry BRCA2 mutations have a lifetime risk of breast cancer of about 45 percent, and they also have an increased risk of developing other cancers, especially ovarian.
Women with a BRCA1 mutation have an average risk of developing breast cancer of about 55 to 65 percent, but an individual’s risk may be as high as 80 percent.
